Aromatase is an enzyme that will convert, for example, excess testosterone in estradiol, which is a female hormone. Very important that it is present in quantities suitable too in the male body. Why am I explaining this?
Because in today's video we're going to talk about anti flavorings, something extremely important during some steroid uses anabolic steroids, as well as in your post cycle. So I invite you right now, to click I didn’t like subscribing to the channel today let's talk about anti-flavoring. There are several types of anti-flavorings, which are the most famous?
What are my students asking me the most, you ask me? On Instagram I get questions. Are they clomiphene, tamoxifen, anastrozole, letrozole exemestene these 5 anti flavorings are the most popular within bodybuilding.
Now we are going to divide them into two groups, one group is SERMS. What is a SERMS? It is a specific modulator of a receiver estrogen, unlike a SARMS that is from androgenic.
Leandro Twin already talked about SARMS? Now, whenever you have a question, look for here on the channel: Leandro Twin more theme, which you will find a video of me. And the other will be a group of anti-flavoring of layer 3 generation, which are of the most powerful, which will be within that letrozole, anastrozole and exemestane.
This first SERMS group will enter clomiphene and tamoxifen. First of all, what is the difference between these two groups of anti flavorings? This group of SERMS anti-flavorants they have an efficiency in some receivers specifics.
So, for example: In the hypothalamus receptor, of the pituitary it will act as an inhibitor of estrogen. This second group of anti-flavoring grade 3, will they do that too? They will do that too.
What is a difference? One difference is that SERMS clomiphene and tamoxifen they in some receptors can not only does it not inhibit the action of estrogen, how to act like estrogen. It's really Leandro Twin, and what I'm going to want that?
See I didn't say that estrogen is important in our body? Yes, you did. For example, then: If I have a performance of estrogen in my liver, I can maintain plasma cholesterol levels more efficient.
So it means that this one I'm not going having so much trouble with cholesterol as my second group with anastrozole, exemestane and letrozole? Perfectly. Leandro Twin, why do I want to inhibit, why example, the action of estrogen with this first SERMS group there in hypophysis?
Why you can cancel a feedback negative, let's explain a little more because it's a little dense, but come with me because it’s important for you to know that. When you take this first SERMS group and they act on the pituitary gland, they inhibit negative feedback from hormones sexual. So what does that mean after all?
I mean there is a feedback, that is, a feeding and when you have a sex hormone in high, the body sees no reason to manufacture this sex hormone, because it already has it into the bloodstream. If I inhibit this mechanism, even though a sex hormone, the body cannot do the reading of this sex hormone and starts to increase his production. You will say: Leandro Twin, but for what reason why I would put an inhibitor of estradiol, and at the same time it would manufacture estradiol if it continues to be inhibited, that is, in the end would it be the same?
So it would be the same doing this analysis estradiol only. Now when we involve sex hormones have testosterone, and that’s what it’s all about SERMS. They will inhibit the action of the female hormone estradiol, and force the body to produce more sex hormones.
The female hormone you don't need to worry about, because he's already inhibited, now in this case you will have a testosterone release. So releasing testosterone increases your free text, your total text. Leandro Twin and what is it for?
In a CPT, where I have a testosterone low, and perhaps a high estradiol, can be very welcome to help recover the axis. So, normally, the tamoxifen and clomiphene as they have a lower estradiol inhibiting effect than this second group, which is much more powerful, you use it normally in TPC. During the cycle it also has the power to inhibit estrogen and for example, decrease fluid retention, acne?
It also has this ability. Leandro Twin, but why is it not so used like this? Because they have some characteristics aversive to those seeking the gain effects muscle mass, and fat loss as, for example: Decrease in IGF-1, you decrease the IGF-1 takes power of your cycle.
It also increases SHBG, which is a molecule which binds to total testosterone and does not allow that she is free, and not allowing to be free you have no efficiency of this little grain of testosterone. So even though it’s at a low incidence are anti-flavoring, which we don't usually used in steroid protocol anabolic steroids that will flavor, we will already talk about it. So, they are usually used in TPC.
Going to our second group, this second group also does this to reduce estradiol, and force the body to produce some testosterone, but here's how a lot of aggression from estradiol, it needs much greater care with the use of these three namely anastrozole, exemestane and letrozole. I can use them at TPC for that same principle? It can, but when they are used at the CPT instead, or even in association, with extreme caution with SERMS?
Normally when estradiol is too high. So, I entered TPC with the testo very low and with very high estradiol. One thing that will not happen, for example, in a cycle of Oxandrolone, Stanozolol, Masteron from Primobolan, because none of them have an aromatization process in your body.
So you're not going to go into TPC with estradiol high with such a protocol. When can I enter TPC with estradiol very high? When I did a testosterone cycle with a very high amount, because the excess converts, not all testosterone.
So when you use a drug that flavor a lot, you can enter the TPC too loaded estradiol, to the point of tamoxifen and oclomifene not being able to control this situation. But usually in more modest cycles, the what we observe is that it is not legal to do use, there is no need for anastrozole, exemestane and letrozole. And they are used, so when during an anabolic steroid protocol, precisely when that anabolic steroid protocol involves drugs that increase the process of aromatization, conversion of testosterone in estradiol.
So when you take a cycle that estradiol it's high, you use them to protect. One thing that we cannot pass up beaten, this is extremely important, the very low estradiol causes harm to our body, for example: Dyslipidemia, then you will have your cholesterol changed. You will have more succession to joint injuries, because estradiol is a hormone that lubricates, also lubricates the skin, so the skin tends to get very dry.
You can have a really bad mood, you can be very stressed, very nervous, because it is a hormone that makes you a little bit more depressed, but from the point of view of not being anxious, being bad with that. It also has everything to do with libido, so some people are using too much testosterone, and very anti-flavor, and says: Wow my libido dropped, will this testosterone is it false? It may be that your estradiol is less 20, and this is not advisable.
Most gurus will indicate, more or less at least, somewhere around 30 to 80 estradiol. When the number starts to get too high you also have some harm, for example: Too much fluid retention, lots of acne, very oily skin, your love can get too depressed, start to get melancholy, you may have a gynecomastia. Has Leandro Twin ever made a video about gynecomastia?
Already, always have a question: Leandro Twin more theme, don't forget to always search. So estradiol should not be too high, but we have to remember one thing, the high estradiol it has anabolic power. So if you get 110 of estradiol and can handle collateral very well and you have 80, know that 110 is more anabolic.
Now, you can't go too high on estradiol, because otherwise, precisely, you will have collateral like a gynecomastia, which it will not compensate for this anabolic effect. Leandro Twin what is the difference from exemestane, of anastrozole and letrozole, all are class 3, which is the most powerful class anti-flavoring? Yes.
So what's the difference? The difference is the hierarchical scale of power inhibitory, so the most potent of these three is going to be letrozole, so it becomes the most dangerous. Why the most dangerous?
Because precisely if you make a mistake in his hand, you can reset your estradiol and have all the problems that I have already posed, and it may take to come back, make it clear. So letrozole is usually used in a very powerful cycle from the point of view to raise estradiol, and always with extreme caution, clinical exams, even though everything it is more appropriate to do clinical examinations especially if you have no knowledge, letrozole is very delicate. So we have to be careful, because he is sly, he can really screw up with your life.
After letrozole we will have exemestane, it is stronger than anastrozole, and more weaker than letrozole. Leandro Twin what we have to take a lot careful here? That it also has a very high power, and it destroys the aromatase enzymes.
And what does it mean? I mean he connects there, he cancels that enzyme forever. So it means that if I take it I will never but will I convert testosterone to estradiol?
That's not it, I said that that enzyme is unusable forever, but the body seeing testosterone circulating around, it will create new so that manage to deal with the problem. Anastrozole no longer does this, and why am I citing this difference? Because anastrozole for not doing that, when you discontinue use at once, so gross, you may have a rebound of estradiol.
Because look, in the example we canceled, then go get extra circulating, the body has been coming back to build, and then everything is back to its normality. In anastrozole no, the enzyme is still there working, and what happens? You will take this off and you will have many receivers, because they were not canceled and you have a super conversion in estradiol, and this generates a very rebound unpleasant.
So anastrozole is usually more indicated that you wean but not not necessarily all cases that anastrozole needs weaning at sometimes it can happen. Look, let's assume you're going to finish your steroid cycle anabolic, and will end anastrozole together, in the sequence you will enter a TPC, and in this TPC you will already put, for example, tamoxifen. So in that case you will not suffer a estradiol rebound, because you are entering with a second drug to control, which will play the role in TPC, and will play the role just the control of the anastrozole rebound.
So if you come discontinuing little by little, and put tamoxifen together you can have an even bigger problem, which is to reset estradiol again. Because you come with estradiol very low, put one more thing to counteract its effect. Then you start to realize that the anti flavorings they are very careful in time to use, because it can be very expensive.
And clinical examinations are the most efficient for those without knowledge of putting a dose leaves one, two weeks, take an exam, see how it's going and so you don't tend to make mistakes. Just out of curiosity, SERMS clomiphene and tamoxifen are older, were created in the 60's, thinking about breast cancer, and reproduction system female and male also clomiphene, they are the ones that have more studies until today. They were introduced to bodybuilding, more or less, in the 70s, 80s and then people managed to put more hands in testosterone.
So we were afraid to put too much testosterone and reason, because it had an aromatization process very strong. And when they came on stage nearby 1980s, to be more punctual, the people started putting more testosterone in anabolic steroid cycles, and you notice this in the physique of bodybuilders analyzing every decade. In the 1980s, beginning of the 90s, the other anti-flavorings letrozole, anastrozole and exemestane.
And why did they come later? Because SERMS was not being sufficient in some cases of cancer breast cancer, so I needed an inhibitor of greater estradiol. And then he created this new generation of class 3 anti-flavoring for just purposes therapeutic factors, letrozole came to be used in cancer in a very advanced, precisely because its power estradiol inhibitor is much higher.
So let's talk a little bit about the application practice, when you do a steroid cycle anabolic steroids you have to measure how much it can increase its flavoring, the your estradiol. So if you are going to cycle with testosterone in a very small amount, almost a TRT, and another oxandrolone you don't even need of anti flavoring, because you will not experience an increase in the relevant estradiol. Remembering that estradiol a little higher with testosterone taller no problem, the problem is high estradiol with low testosterone, this scenario is bad for our body.
When the two are more or less high and balanced, as long as there is no side effects such as: A lot of acne, gynecomastia, nipple pain, you don't need use anti flavoring. According to the power of this cycle: Ah doubled testosterone, I tripled. I can come in with the most subtle anti-flavoring, I don't need use a very aggressive thing, I will use a smaller quantity, and so on.
If the cycle gets stronger and stronger, the more I I will need inhibitory power, and I can go up the scale of my drugs. Among these three drugs the most dangerous will still be, despite letrozole as more strong, and anastrozole as the weakest, and the exemestane in the middle. Exemestane will be the safest drug, because it’s not as strong as letrozole, and it doesn't rebound like anastrozole.
So the preference of most bodybuilders it will be an example. In a CPT, on the other hand, clomiphene and tamoxifen tends to be very subtle of side effects, and big errors in dosage, in use not generate great collateral. So both are very well accepted, but most people who work with this hormonal part choose more tamoxifen, it turns out to be a little more efficient than clomiphene in an empirical experiment.
Guys I talked a lot here about cycle and about CPT, and I would like to talk one more thing, there is a way to cycle 100% safe and without collateral, I said one little bit in this video, why if you to make that use there is a way less aggressive, more ideal for our body. So check out this video here.
