Hi, my name is Dr Peter Lee. Here at Wave Plastic Surgery, today I want to talk about a real sort of revolutionary medication that really helps us fight weight loss in patients, and that is uh th appetite or Muro. This is one of the newer medications for actually diabetes, what we call GLP1 Agonist or glucagon-like insulin the trop big polypeptide Agonist.
Previously, there have been other medications that work the same way, such as WOVI and CENDA. However, this is the first medication that actually works at another receptor called GIP, and we think that works synergistically to help patients lose weight by number one losing appetite. They don't feel like eating, and it works in the gastrointestinal area to cause early satiety, that is, the feeling of fullness after eating even just a little bit.
The food doesn't move particularly fast in the GI tract; it stays in there so you keep on feeling full. Patients don't feel like eating; they don't have a sense of hunger, and even if they eat a couple of bites, you feel full. By working in this way, it has clearly demonstrated both in terms of consistency as well as the amount of weight loss that it works better than any other medication that has so far been developed.
The way that we know this is that last year, in July of 22, in the New England Journal of Medicine, where they took over 2,000 patients, divided them into four categories where one category had Placebo, the second had 5 milligrams, the third had 10 mg, and the fourth had 15 mg. They did all of this with changes in lifestyle as well, where they adhered to a certain diet as well as exercise. What they noticed in the group of the placebo was about 3% weight loss, and that's what you would expect with changes in lifestyle.
With 5 mg, they noticed 15% weight loss, with 10 mg, they noticed 20%, and with 15 mg, they plateaued at about 21%. Based on this, it really blows away the efficacy of other medications previous to this. For example, phentermine, which is a common oral medication that people take to help lose weight, results in about 5% weight loss.
With CENDA, which is the first line of GLP1 Agonist which you have to inject on a daily basis, it resulted in about 8% weight loss. Then in 21, WOY came into the market and resulted in about 15% weight loss, which you had to inject on a weekly basis. And now, with th appetite or Muro, that in a therapeutic range which is around 7 1 12 to 10 mg you can expect to lose about 20%.
This is also a weekly injection medication. We have actually seen some patients who are not really obese, who just have that extra 10 pounds that they want to lose, and it has really worked for them as well. In terms of side effects and tolerance, for a lot of people, it's usually just gastrointestinal side effects such as nausea, diarrhea, and constipation.
In some patients, they feel a little bit weak, and you would expect that obviously with a decrease in food intake. Some people feel they have a little bit of musculoskeletal pain associated with it. There has been a previous study on mice showing some effect on thyroid carcinomas, but certainly in every single human study, there has been no association with thyroid cancer.
Right now, Muro is not a weight loss medication; it has not been FDA approved for it. However, it is on FastTrack Pace to obtain FDA clearance. Currently, it's a diabetes medication.
In summary, we really think that th appetite is a game changer to fight obesity as well as just weight loss in general. But obviously, you have to incorporate changing lifestyle as well. One of the things that patients have been asking is what are some of the common side effects, so let's tackle on the most common side effect.
Quite honestly, for most people, nothing. A lot of patients really don't feel any adverse reactions. The only thing that they feel is what's therapeutic, which is loss of appetite and early satiety.
However, some patients do experience nausea, diarrhea, or constipation, the GI symptoms. This is really dose-dependent and how acclimated they are to the medication. That's why it's so important that when we first start patients on th appetite, they start off with a small dose, and that has significantly reduced the degree of nausea, constipation, or diarrhea.
Some of the other reported side effects associated with th appetite are things such as higher heart rate, fatigue, sleepiness, but quite honestly, if we look at all of our patients, that type of complaint is extremely rare. Again, it has to do with slow incrementation of the dosage that we use. Th appetite comes in increments of 2.
5 mg, so a lot of times we are starting patients off at 2. 5 mg or in some patients 5 mg, and we slowly increase that dosage by 2. 5 mg.
What we have found is that that has been extremely effective in controlling GI symptoms. One of the other questions that some patients have is, do I have to take this medication forever? Now that's true for diabetics, right?
I mean people with type 2 diabetes may be able to stop, especially if they can actually get their weight under control. But until that period of time, they have to keep taking the medication almost indefinitely. However, for weight loss, that is still a question out there because there hasn't been a real large.
. . Studies that explore the weight loss and what the regimen should be.
What we can tell you is that, in our experience with our patients, they can stop and continue to sort of have that weight under control. Or, in some patients, even after they stop, they keep on losing weight. And we think that the reason why is they have early satiety.
That even after eating a certain amount, they get full quicker than in the past and they can't eat as much as they used to in the past. The other reason why we think this happens is that we continue to stress Lifestyle Changes even when they're on this medication. It really is important to, number one, make sure that you eat the right type of food - well balanced small portions, maybe two or three meals per day.
The other thing is, obviously, continu. . .
The rest of the text was omitted as it exceeds the character limit for a single response. If you would like me to continue fixing the punctuation in the remaining text, please let me know. Been on his appetite that they still have that early satiety, and like most things, once patient starts losing weight, there is this momentum that they have and this positive sort of encouragement that they have.
So that carries through in their diet and exercise regimen. If you like the contents of this video and you found it to be helpful, please hit the like button as well as subscribe to our channel.
