in this video we will talk about cancer Immunology as we know that Immunology is the branch of biology that deals with the study of immune system whereas cancer is a group of more than 100 distinct diseases that are characterized by the uncontrolled growth of abnormal cells in the body so here in cancer Immunology we will learn about the relation of cancer with the immune system for over 100 years there was consider controversy about the role of the immune system in cancer and particularly whether individuals made immune responses against two more cells like it does in
case of any parasite or bacterial or viral infection this question arises because of the fact that bacteria and viruses which can be effectively recognized and controlled by the immune system consist of a variety of foreign proteins or we can say antigenic determinants that are capable of initiating immune responses against them tumor cells on the other hand differ only slightly from normal cells sometimes truncated or mutated proteins are present but otherwise the cells use normal biochemical Pathways even if some proteins are expressed as levels higher than normal or if fetal antigens are expressed these are in
most cases normal cellular proteins and so they can't be recognized as danger by immune system also in many cases if mutated proteins are present only few peptides can be potentially recognized as foreign by immune system so it has always been a major limitation but it has long been suspected that the immune system may be able to recognize tumors and Destroy them as it does in an allergenic transplant or a parasite this monitoring process of immune system by which cells of the immune system Det protect and Destroy neoplastically transformed cells or simply tumor cells in the
body is called immune surveillance but a number of findings indicate that immunos surveillance against tumors is not one of the primary tasks of the immune system as patients with severe immune defects such as HIV do not exhibit an increase in the most common cancer types except they have an increased incidence of virus Associated tumors only as such patients are more prone to infection but it's not specifically for tumors but some recent findings of experimental animal studies do justify hope that manipulation of the immune system can result in effective immunotherapy strategies so later in this video
we will learn about these strategies of immunotherapy but we will start our video lecture by discussing tumors related to immune system mainly lymphoid tumors in which we will learn how genetic alterations and interactions with pathogens lead to tumors of lymphoid cells after that we will discuss what are the tumor antigens with their different types then we will look at some Escape mechanisms that tumor cells adopt to avoid immune responses and lastly we will learn how the immune system can respond to tumors and how this knowledge is being turned into new tumor immunotherapies so without wasting
time let's dive in don't forget to download our apps so you can watch our video lectures anytime anywhere [Music]
