Best Time To Inject Steroids | Science & Biology-Based!

allowing the steroid molecule to attach to the Androgen receptor and start that sweet anabolic process resulting in more muscle mass vigorous Steve here what is the best time to inject gear one of life's biggest questions when is the best time to administer these anabolic antigenic steroids which is going to increase our muscle mass and improve our overall sense of well-being well long story short let me give you guys a spoiler alert the best time to inject is before activity ideally in a fasted State now with that out of the way let me explain stick around

you might learn something new but before we do please like the video leave a comment for the algorithm and consider subscribing if you haven't already before I explain how I came to that conclusion I must first explain what happens after you inject steroids and for the sake of this video we're going to limit it to the Esty steroids the testosterone initate or the Nal decanoates the tremone acetate for example because those have different pharmacodynamics compared to suspensions being testosterone suspension or windol suspension now after Administration the carrier oil and its active pharmaceutical ingredients disperse throughout

the muscle a injection Depot is not a perfect sphere it will disperse throughout the muscle taking all kinds of shapes and thus increasing its surface area and as this carer o disperses lipases which are enzymes which break down fat will start to act on the surface of this injection Depot slowly metabolizing the fats into free form fatty acids monoglycerides diglycerides or triglycerides so that means that the caror oil that you're administering has slight caloric value monoglycerides diglycerides and triglycerides contain calories now assuming that a 1 ml Administration contains about 50% 75% carer oil which can

be broken down by lipases each administration of 1 ml will yield approximately four to seven calories keep that in mind so if you're administering 3 milliliters per week for example that's not so much additional calories that you're administering maybe 12 to 21 calories through an Exogen Administration it should be a non-issue but still something of note which I wanted to mention in this video and as the injection Depot turns into several fat droplets or multiple injection Depot this further increases its surface area allowing more light bases to metabolize the fat away as these small fat

droplets metabolize the surface the overall surface area gets less prolonging the duration of which these eside steroids end up in the extracellular space so in the beginning you see a very rapid peak in serum concentrations after which they Decline and it mostly has to do with lipase enzyme activity and the overall surface area of the injection Depot first it goes up and then it comes down so ultimately it's the overall surface area of the injection Depot which determines the rates at which Esty steroids gets liberated from the injection Depot and ends up in the extracellular

space within the skeletal muscle now this is also called the intital space and once the ride steroid molecules are there they can proceed to enter Central circulation for them to be metabolized in other tissues and keep in mind that eside steroids are not the active pharmaceutical ingredient they're merely a prod drug and they're only active after the Ester has been metabolized from its steroid molecule and that brings us to benzo benzoate and benzo alcohol benzo benzoate is a solvent excipient commonly used in estrop steroid formulations to increase it solvency and allow the pharmaceutical ingredients to

be suspended in a carrier oil now benzo benzo disperses from the injection Depot quite rapidly certainly a lot faster than most carrier oils with the exclusion of MCT oil and it's the same as Beno alcohol which is a bistatic preservative and local anesthetic also disperses from the injection Depot quite rapidly certainly a lot faster than the carer oil which needs to be metabolized by lipases so now we have benzol benzoate and benzol alcohol both metabolizing and dispersing from the injection Depot rapidly and thus acting as a pro- drug delivery method of the Esty steroid which

is contained within the injection Depot so not only does the lightbase enzyme activity contributes to the rate at which eside steroids inter Central circulation benzo benzoate and benzo alcohol also contributes because they disperse the eside steroids throughout skeletal muscle quite rapidly and keep in mind that benzo benzoid and benzo alcohol metabolize quite rapidly also now it is have note that both of these compounds can potentiate some toxicity in several tissues of the body so they should be metabolized and excreted from the body as soon as possible benzo benzoid metabolizes or hydes into benzoic acid and

benzol alcohol and ultimately benzo alcohol also metabolizes into benzoic acid itself benzoic acid is rapidly excreted through the urine it has a serum halflife of only 16 minutes so knowing this it's very important to stay hydrated because hydration helps with the excretion of benzol benzoate and it's metabolized which could have a potential negative effect so ask yourself this at which point during the day am I most hydrated it's probably during your workouts or during fasted cardio which most people drink at least a liter or one half liters of water as well so again make a

mental note of that it will lead into the conclusion which we'll discuss a little bit later in this video now Beno alcohol depletes from the injection Depot within approximately 52 hours that means a little bit over two full days Beno alcohol helps with the delivery of the pro drug being the estrop steroids into the intital or extracellular space allowing it to be absorbed into Central Circ ation only within the first 52 hours after Administration so that means that regardless of Esther you need to administer your steroids at least every two days now again Beno alcohol

depletes from the injection Depot within 52 hours with this information we can um estimate that the half-life of benzo alcohol from an injection Depot is approximately 10.4 hours let's say between 10 to 10 and a half hours but unfortunately I can't find this information for benel benzoid I can't find its halflife nor can I find the rate at which Benz of benzoate completely metabolizes from the injection Depot that information is currently unknown so we can only base the rate of the injection frequency based on the rate at which benzo alcohol metabolizes from the injection Depot

being every two days or so every 52 hours now like I mentioned before once the estrop steroid molec ules have been liberated from the injection Depot they can finally enter the central circulation but the central circulation is actually composed of two separate systems we have the cardiovascular circulatory system and the lymphatic system which is actually a one-way system the right quadrant of the lymphatic system which includes the right part of your torso your right arm and the right part of your face it all drains into the internal jugular vein located here approximately and the other

part of the lymphatic system including the lower right side of your body drains into the subclavian Vein on the left side of the body located here now both of these veins lead into the heart so the fluid that moves through the lymphatic system eventually ends up in the cardiovascular circulatory system through these two veins now the cardiovascular system is circulatory because the heart pumps blood first through several different organs it goes to the lungs to be oxygenated it goes to the intestinal tract to be enriched with nutrients and passes through the liver in the kidneys

to be detoxified then once the heart pumps blood to various tissues of the body through the veins ending up in the capillaries it is in these capillaries that the blood plasma can diffuse into the intertial space containing the oxygen and the nutrients and of course fluid which helps to dissolve and disperse these estrop steroid molecules which is now present in the skeletal muscles where this administ ation took place now in the average human approximately 20 L of fluid exits the capillaries into the interstital space but only 17 liters of this fluid returns into the cardiovascular

circulatory system through this capillary blood vessels and it's this remaining three lers of fluid that coincidently ends up in the lymphatic system and then returns to the cardiovascular system through the two veins located in your neck now for this to happen the lymphatic system relies on movement it doesn't have a pump like the cardiovascular system has in the form of a heart which pumps blood around the lymphatic system is reliant on skeletal muscle contractions which kind of forces the fluid through the lymphatic system eventually ending up in the two veins in your neck so you'll

need to do movements for this 15% of fluid that doesn't return into the cardiovascular system to end up in the cardiovascular system but first passing through the lymphatic system again if there's no movement in the body you're completely sedentary I'm sure many of you guys have experienced when you're on holiday and eating a little bit too much Foods there's a lot of delivery of nutrients in the through the cardiovascular system to the peripheral tissue and when there's no movement this fluid remains you start to get edema in places you did not expect maybe even your

hands your face obviously your ankles because the gravity kind of P pulls it down this is because the lymphatic system requires activation through movement and if you're not performing any movement this interal fluid remains in place so knowing this information of how the central circulation works we can assume that 15% of the esopi steroid molecules are going to end up in the lymphatic system ultimately getting drained through the subclavian vein or the internal jugler vein right into the heart and and the other 85% is going to enter the cardiovascular system directly through the capillary blood

vessels which are located within skeletal muscle so what we want after the administration especially within the first 52 hours we want a very high turnover of the interstital fluids to end up in the cardiovascular system as well as in the lymphatic system and for that we need Movement we need movement to activate the lymphatic system and we need to increase heart rate to pump more blood throughout the cardiovascular circulatory system paired with proper hydration that allows for more fluid to enter the extracellular interstial space allowing the eside steroid which just was liberated from the injection

Depot to diffuse through this fluid 85% of this fluid containing the eside steroids will end up back into the cardiovascular system which has now higher turnover because the heart rate is increased and through activity the lymphatic system gets activated by movement along the remaining 15% of this Esty steroid to end up in the cardiovascular system ultimately for it to be transported to tissue where the Esther can be metabolized from its apparent hormone allowing it to become pharmaceutically active and interact with the Androgen receptor or other receptors which it might have moderate affinity for now the

key here is after all of this absorption and metabolism and circulation is that the estrop steroid need to be metabolized by esterases specifically carboxy esterases which is a family of esterases which metabolizes Esters from steroid molecules or Esters from other medications I mean caroal esterases are involved in the metabolism of many different kinds of pharmaceutical drugs including anti-platelet drugs Angiotensin converting enzyme Inhibitors Angiotensin receptor blockers cental nervous system stimulators and several narcotic analgesics now luckily for us carboxy esterases are found in most tissues of the body they're found in very high concentrations within the liver

and the intestinal tract but they're also present in skeletal muscle the kidneys and even white and brown fat there was a study performed on mice where they looked at the tissue distribution of the messenger RNA for corosal estasis family 1 to5 within several different tissues again this is a mice study but I'll put it on the screen nonetheless and Link it down below so you have a little bit of an overview which tissues contain particular corosal esterases but unfortunately I can't find any mapping or correlation between specific genes and certain estrop steroid molecules all I

can determine from these studies is that the liver contains many different kinds of caroal esterases from the different families and a very large amount and skeletal muscle contains a select few carboxy esterases families or subsections of a particular family at a very low amount so from this data we can determine that eside steroid molecules are predominantly metabolized and turned into its active pharmaceutical ingredients being the actual steroid molecule within the liver within the liver guys so now we know that we need to perform some activity we need to know that we stay hydrated and we

need to make sure that our Liver Health or our liver activity is optimal for these eside steroids to be metabolized now I'm unsure if consuming a meal has a negative effect UNC carboxy estr enzyme activity but I do know that liver metabolism almost shifts to a polar opposite going from a fastet state to a Fed state so after fasting for about eight hours or 10 hours overnight liver metabolism is significantly different compared to after eating a meal in the form of breakfast for example where the liver is actively trying to store or restore liver glycogen

stores and try to detoxify and metabolize all of this food which is now coming into the stomach in the intestinal tract so liver metabolism changes significantly going from a fasted state to a Fed State and you can see this in the insert of many different medicines take this medicine upon waking in a fasted State now how much that we can extrapolate to the use of estrop steroids a little bit wishy-washy right a little bit the dubious extrapolation but still I would say that liver metabolism is probably more favorable for carboxy esterases metabolism of estoi steroids

in the morning right when you're properly hydrated so the only thing that's passing through your liver is fluids allowing the estat steroids to circulate through the liver metabolize return to the central circulation so it can potentiate their anabolic effects on tissues something of note it is a little bit dubious but again I'm just extrapolating from the medication inserts that I've read throughout the year but from this data we can assume that there is a slight localized effect at the site of administration again because the eside steroid diffuses into the inters cular space might end up

into cells of skeletal muscle where caroal esterases will metabolize the Esther away allowing the steroid molecule to attach to the Androgen receptor and start that sweet anabolic process resulting in more muscle mass still I think most people would mistake localized inflammation from the administration for actual acru of muscle tissue but if you were to compare the localized effect of a steroid Administration within skeletal muscle to a steroid Administration within subcutaneous space regarding its possibility for fat loss in the white fat tissue I would say that those results would be pretty comparable again they would metabolize

due to the carboxy esterases present in both tissues but I would say that the results are marginal at best marginal I mean if you want localized sight enhancement I would look towards the peptides and if you want to look towards localized fat loss I would look into glucagon injection or helos injections which contain clenbutrol and yohimbine I would not consider spot injections of estat steroids into adapost an attempt to facilitate fat loss even though some fat loss is clearly Androgen mediated I think there's much better solutions to accomplish that goal again there's very limited data

on carboxy esteras activity in various tissue so right I just thought I'd mention it here because it is of note something interesting something to consider um if you're thinking about localized side enhancement through steroid administrations it is of note that red blood cells themselves also contain carboxy esterases so as the Esty steroids enters the cardiovascular system into the Bloods the red blood cells within the blood will absorb some of the eside steroids and metabolize them into its active pharmaceutical ingredients allowing it to become active and attached to the Androgen receptor Now red blood cells themselves

don't have receptors but white blood cells do and I was not able to find a study if there's a correlation between steroid intake the amount of red blood cells within the bloodstream right your overall red blood cell count in your hematic levels to see if that reduces white blood cell count concentrations further because it is known that the free Androgen index or the amount of free androgens within the bloodstream not bound to albumin not bound to sexual bining glob and don't contain an Esty attachment rendering it physiologically inactive free androgens in the bloodstream are known

to lower white blood cell count concentrations now that could also be because some of the eside steroids travel through the lymphatic system which is part of the immune system so there's a little bit of an overlap there but again these are studies which still have to be performed but it is of note that eside steroids do metabolize in the bloodstream albe it to a very low extent right not to the extent that eside steroids are metabolized within the liver or the intestinal tract and probably not even to the extent that they're metabolized in skeletal muscle

you will have an individual preference to particular steroid Ester molecules so what I've noticed myself my individual caroal esterases from all the different families that are out there in the different genes in different organs and tissues my body prefers anate some people people prefer cypionat Some people prefer propionates Some people prefer acetates so through a little bit of experimentation you'll have to figure out which Esther your body prefers best based on your individual carboxy esterases production within different tissues of your body allowing you to determine which Esther you can probably get away with for the

most stable serum concentrations the least amount of post injection pain because there's not so much metabolism at the of administration but the metabolism happens in other tissues so again there's many different kinds of caroal esterases classified into five different families and since we don't have any mapping between these families in particular steroid Esters you're going to have to undergo some self-experimentation to figure out which Esters work best for you I would love to say that I did all of these experiments so you don't have to but in this case it highly depends on your individual

makeup so you'll still have to go through the experimentation process so maybe it's a quick way to figure it out you can try testosterone inate and Mone inate for a while and then switch to the exact same dose of testosterone proprionate and Mone proprionate I'll do the calculations on the screen so you don't have to at least I can help you in that sense so you get the exact same amount of steroid molecules right the the testosterone dose is exactly the same and the Mone dose is exactly the same maybe with the same Administration frequency

of doing daily administrations you might notice a difference between the initate formula and the propriate formula now unfortunately trimone anthat you could try but there's no trimone proprionate for example so again you'll have to match the Esters accordingly to figure out which individual caroal esterases seem to favor particular steroid Esters in your individual scenario so after all of this discussion an explanation of human biology of what happens after a steroid Administration we can summarize a little bit and say the following it's probably best to stay sufficiently hydrated following a steroid Administration it's probably best to

perform moderate physical activity to increase systemic circulation whether that's the cardiovascular circulatory system or activating the lymphatic system through movements you might be able to take 1,000 milligrams of torine to help balance the osmotic pressure between the intercellular and extracellular space again allowing this interal fluid to pass through the capillaries and the extracellular space into the lymphatic system unobstructed it's probably best to stay away from food for optimal blood flow and unimpaired metabolism within the liver allowing these Esty steroids once they finally end up in the liver to be metabolized by the carboxy esterase enzymes

all of this that we know now in which situation do all three points match fasted cardio and if you're doing daily administrations of 25 milligrams toost anate or 50 or a whole slew of compounds containing a car oil and benzo benzoate and benzo alcohol you do your daily fasted cardio as well probably a 40-minute video to tell you to do your daily fasted cardio but this is what it takes for you [ __ ] to get on the elliptical I have to bait you in with steroid topics to end up at doing daily fasted cardio

man the things I have to do to prevent your heart attack all right I'll leave it at that thank you guys so much for watching if you're looking for the most comprehensive guides to bodybuilding pharmacology you can find the eBooks on my website St oh man I'm sorry guys um yeah let's let's continue personalized advice always available through consultations you can find the rids in the consultation section following Instagram and Tik Tok at Vigor Steve have a look at my new workout Clips Channel called Vigor to the max where all my awesome sets are documented

when I train in the morning you bit your lift testicle I administered some anabolic steroids about an hour prior yeah let those esopi steroids circulate metabolize in my liver to return to the SC to musle and potentiate some front double bicep action Vigor scw you guys know what to do much appreciated much love sorry for all the laughs and jokes at the end but yeah sometimes I got to bait and switch you guys so you can get your education in by Yours Truly Steve out