well a war welcome to this talk now today I want mostly to be looking at this paper here uh I Ting a potential anti-cancer drug derived from an anti-parasitic drug published in the peer- review journal pharmacological research now as you would expect this wasn't published in the United States or the United Kingdom of Australia or New Zealand or Canada this is actually research from China so let's get straight into it now now is there a plausible mechanism of action is the first question is it is it is it conceivable that this could be true well
it gives various mechanisms of action in the paper and we're also going to be looking at some specific cancers which the researchers feel this is is efficacious for let's start off with uh mechanisms of Action Now what they say is IV me induces different program cell death patterns in different tumor uh cells so this is the key thing programmed cell death patterns so what seems to be happening here is the body's own way of killing its own cells is activated to kill cancer cells which of course is exactly what is required uh in in cancer
to get rid of these cancer cells uh the main form of IX an induced program cell death is apoptosis so they're saying icin is inducing program cell death now apoptosis is just programed cell death so like when you were uh before you were born you had tissue between your fingers and there was apoptosis of the tissue that was formed between the fingers that's why you have separate fingers so apoptosis is a perfectly normal process it goes on in later life as well and this is stimulating according to these researchers stimul stimulating apoptosis in cancer cells
uh autoag is another one basically self-eating like Lal dependent form a program cell death so lomes Lal Lyme is an enzyme inside cells that can destroy and digest cells and proteolysis is an inflammatory based uh is a pro protot Tois is an inflammatory based mechanism inflammatory cell death induced by inflammasomes these are components in the cytoplasm of cells again which will cause inflammation and destruction of the of the cells so mechanisms there do appear to be plausible in if you look at the paper um now the paper is somewhat complicated I think it has to
be said but if you look at it it talks about the different types of uh cancers and it also gives some plausible mechanisms in diagrammatic form now these are quite biochemical I don't intend to run them through run through them all but um they have plausible mechanisms of action that could be working here for example that one to generate apoptosis and uh another one here to generate another form of cell destruction uh autoag and they also have a diagram that illustrates potential mechanisms of action for um uh for the uh proteo proteo ptosis cell destruction
so um not ludicrous at all but of course the key thing is does this work in real life let's just stop now I want to play a short clip from uh a cancer surgeon in the United States this is uh Dr Kathleen Ruddy some links for her there she's a cancer surgeon researcher an author uh in the United States let's get her clip now and then we'll come back and think about it and I was not really even familiar with those people who use ior macton um and so when in the early days of Co
when it became clear that ior mden was effective in preventing and treating patients with a SARS K2 infection um I began to be aware having looked in the literature that there was 20 years of research showing that Ivor mecin had great potential in the treatment of cancer I was introduced to a patient with stage four prostate cancer had received two vaccines perfectly healthy marathoner no history of cancer in the family two months after his uh second fiser shot works with the government was going to lose his job in his pension if he wasn't vaccinated um
he was diagnosed all at once with stage 4 prostate cancer he tells a very compelling story melodramatic story about that 24-hour period of time in his life and he went through the traditional protocols radiation chemotherapy radiation chemotherapy pharmacologic castration all of it over a period of 9 months and then his doctor said you know there's really nothing else we can do and uh his name is Paul man and he was like can't you give me more radiation no can't you give me more chemo no aren't there any other drugs no are there any clinical trials
there's nothing hospice send for the priest so a friend of his knew me and she said uh would you give Paul a call he just needs some moral support something so I said sure So I began calling him we spoke about once a week for 3 weeks and finally um the poor guy was suffering had cancer and 11 bones in his body his right leg was completely swollen obstructed with tumor he's miserable and I said Paul I don't know if this is going to help you but I know it's not going to hurt you I
just can't imagine based on my judgment and understanding of the scientific literature and all the work that drors Corey and Merck had done and others around the world that Ivor maon would hurt you it might help I can't say so he said you know I'll give it a try and uh he drove to Tennessee where you could get it without a prescription PS I discovered last night having dinner with Paul and his wife Terry he drove from where he lives in Missouri to Tennessee and paid cash for his I macton that's it he didn't submit
it to insurance company he didn't tell anybody back in Missouri is on College just no his icin prescriptions are listed in his chart how did that information get from the pharmacy in Tennessee to his chart in Missouri we don't know somebody does I'd like to know myself anyway he starts taking Iber maon and he doesn't have any problems with it and I talk to him every week and um how are you feeling well no change next week uh maybe a little bit better I don't know how's your leg it's not quite as swollen how how's
the pain pain everywhere maybe a little bit better slowly slowly slowly not getting worse not necessarily getting better not getting worse fast forward um two month follow-up appointment at the clinic they didn't expect to see him okay Paul um he's feeling a little bit better they do a PSA which was off the charts to begin with and if I'm not mistaken at the time they randomized him to hospice I think it was in the hundreds maybe 700 800 what does that mean exactly for the late person over four would be abnormal MH okay so what
are we talking about here prostate cells normally secrete a protein prostate specific antigen it's one of the things that they do cancer cells that originate in the prostate that are dividing rapidly and growing fast are spitting out PS mhm okay it's not that they're contributing to the body economy in any way it's just they just want to multiply and divide and that's the end of the story and so your PSA levels start to rise which is a marker a screening marker oh your PSA was four and now it's eight let's do a prostate ultrasound whatever
so PSA can be a screen for the emergence of a tumor but it can also be used particularly at high levels as evidence for cancer response to cancer recurr of cancer his was I mean it's supposed to be you know four you know yeah it's hundreds okay he goes back for his two-month appointment it's 1.3 they said you're in remission well not you know complete remission he still had the bone Mets but you're in like a biochemical remission well that was good news slowly slowly slowly he begins to improve less pain swelling is okay a
lot of other vaccine injuries however he's getting better he's getting getting better giving him uh nutritional support and other supplements so he's getting better but 9 months later um he's out dancing for 4 hours three nights a week he gets a head to toe uh rescanning and uh three of the bone Mets are gone there no growth of the Mets that are there no new lesions there's only one hot spot and that's where he received radiation therapy and the radiation um the radiologist really could not distinguish whether that was a tumor hot spot or radiation
change um he is doing very well the vaccine injury is uh a problem but the cancer is no longer a problem except for the fact that it's still there and we want to get rid of it completely um and he and he said he called me from a hockey game and he said uh if I didn't know I have cancer I would not know I have cancer can well based on 20 years research stage four prostate cancer over the counter drug in Tennessee and that's from a cancer surgeon researcher and uh author so the thing
about this is icton is a remarkably safe drug and if you're very ill anyway it's hard to think of a reason not to try try things that you might not normally try and obviously what we should do this is patently obvious what we should do is people that would elect to try this should be free to do so under the supervision of their doctors of course and a cohort should be generated and data should be collected and if this was available I think we would get a few thousand patients in the first cohort within a
few weeks because sad we've got people around us dying of cancer now we've so many of you have been touched by cancer deaths I've had so many uh correspondents and comments on that and and um tragic I only mention this because it's now in the public domain but it's a Chris Hoyer diagnosed with stage four prostate cancer uh it's only 48 very poor prognosis with current medical treatment a lot of this around why not try this and develop a cohort let's hope the regulatory authorities are listening and take this on board it's just such an
obvious thing to do so um let's just look at a few other cancers that this paper remember we're looking at this paper here I have tin potential anti-cancer drug derived from an antiparasitic drug data research from China um other forms of cancer that are mentioned in this paper breast cancer is mentioned malignant tumor produced by gene mutations in breast epithelial cells milk producing cells digestive system cancers gastric of course is stomach and hepatocellular liver um again they're mentioned in this paper with some evidence why not try it urinary cancers renal cell that's kidney cancer of
course mentioned in the paper with passible mechanisms of action prostate cancer as we've just heard from Dr Ruddy um hematological blood leukemia reproductive system cancer cervical cancer ovarian cancer again mentioned in the paper with mechanisms of action and a brain Goma gast very poor prognosis respiratory system cancers n of far andil no nose and throat um lung cancer melanoma of the skin um and it's not just here I've just included a few other papers I'm not going to go through them all but there's a few other papers there with references that list these uh potential
benefits now it sounds pretty far-fetched that one drug could be efficacious against cancers in so many diverse areas but if it's um if it is working in this way and it's um if it's disrupting the mechanisms of action which have misplaced now um but if it's disrupting the mechanisms of action that we mentioned the the apoptosis the program cell death the uh the cell death within the cells the lysomal cell death and the inflammat mechanisms of cell death um then if these mechanisms are being stimulated and killing cancer cells then it's plausible and in my
mind even without spending $10 million on a clinical trial people that want to try this should be allowed to not just people that live in Tennessee and data should be collected and cohorts um devel veloped and their progress followed this will cost essentially nothing um if it's completely useless in the vast majority of cases under medical supervision the I is going to be very very very safe drug way way safer than Ibuprofen for example um or paracetamol and a cohort could be developed and amazing things could be learned now of course the downside is that
um pharmaceutical companies might lose sales on really expensive modern patented drugs so that's not all good news um but in my view there's just no reason not to develop these cohorts and make this available to people that would choose to try this let me know what you think we'll leave it there for now thank you for watching
