we now know I Ain would have cured covid in in very ill people it's mean number of studies which are positive yet thought she went on and lied and said it was toxic and dangerous horse only and I think that probably led to hundreds of thousands of deaths because everybody I've talked to who used it nobody has had a death from it and I myself used it on two patients who were really and really ill after they'd had everything else but didn't want to go to hospital uh and they responded to it so I I
know from personal experience it it works so the same government wouldn't let you have that that won't let you have this so why won't they let you have things that we know are very simple safe and effective I mean Iva meon is unbelievably low toxicity it's one of the world's safest drugs isn't it really safer than Ibuprofen or paracetamol or oh far far safer I mean it's given to millions of people around the world and saves the lives not only lives but the eyesight It Center save two million people a year from going blind from
the Feria yeah and yet has antiviral properties and uh should we mention now potential anti-cancer property see we're talking about well I think the fact that there's been Publications on it I mean I i' I recently reviewed an enormous one uh looking at how it could be an anti anti-cancer agent and even I was getting a a little bit tired uh because there were so me many mechanisms it could actually give you some anti-cancer activity this is this is see uh something that I'm very familiar with because I did a lot of work with lamide
at Cene developing lenol lamide and pomalidomide which you know that's what I'm really delighted to say because there was a big company behind that we got those on the market but if it was a small company they would probably just have been pushed away but lenol lamide is number one uh uh for Myoma now even on the NHS I me it's been number one use worldwide for several years but even the NHS means it's first line treatment uh for my it's made an incredible difference the reason I mentioned this with Iva mecin is that we
couldn't believe how many Pathways lenalidomide interfered with and to the point where the company who was funding us to do all this basic research said stop doing it you're finding too many ways it it interferes with things and the regulatory authorities don't like that own conclusion at any rate theide and itin have tremendous similarities and they hit so many Pathways which I believe is why they uh both of these drugs can be administered at non-toxic doses with significant anti-cancer activity and that is an absolute fact established with lenol lamide because of it's been approved Myoma
lymphoma worldwide over 200 countries so an Absol I strongly suspect IA metin would uh uh P pass all those tests too and as well as that these can be used as well as conventional approaches to cancer treatment this is as well as radiother potentially as well as chemotherapy yeah absolutely the when you're talking about using these drugs uh even though they actually work well by themselves you're actually making it more likely they will respond to to other treatments because you're patching up the cves that the other drugs don't deal with you they they get rid
of 80% of the cancer then it starts uh dividing again and goes through the holes that the chemo will never never reach so that that's why I think it's so important to add all this in at the same time and then because there's zero toxicity these drugs as Le a little has shown you can give that for years and the Fantastic thing about that is when you get resistant to it eventually sometimes five years you can add in the pomalidomide which is so similar and it will take over and gain control of the cancer I
mean to us this is just Unthinkable of how the mechanisms are but it happens and it's happened in in several anti-cancer drugs now where there's sequential changes to the the index drug just because it sounds too good to be true doesn't mean it's not true by any means exactly so are these new versions of thalidomide now nonteratogenic that's very interesting they that this was the reason they they wouldn't let us do this theine I I applied to the MRC and the welcome trust and the CR C UK whatever was at the time they all turned
down because my applications because I actually seen patients benefit so dramatically on thei I said we mustn't Chuck the baby away with the bath water they all turn around down my grants on the grounds that we cannot get involved with this it causes birth defects and I said look I'm an oncologist every drug I use causes birth defect not stupid enough to give them to pregnant women and it's very easy to do that too because of its uh origin uh the lenalidomide is very similar to theide it has the same limitations but it's not a
bad limitation it's an oral drug you take every day for a month so you just can't get more than one month without a negative pregnancy test if you're a woman or a man who's breing too I mean it's just just the way they do it um but interestingly the in in practice we know lenide has doesn't have that birth the effect uh but we just have to pretend that it does but it doesn't yeah it's reasonable to be cautious about it yeah that's that's a reasonable precaution as opposed to many of the others that have
been taken so so going back to the the the vaccines that you and others have developed here have you got a company that's up and running and saying yeah we can make these for you now oh IM modulin is the company IM modulin is the company making the IMM 101 and they're ready to go it's and if there's a there's a chart there this is one we published in 2016 it is a very simple multicenter randomized uh trial in which the standard treatment at the time for pancreatic cancer was gemcitabin so all we did was
randomized to IMM or a placebo um in fact not all the places use Placebo because it's obvious if you have a little intradermal injection yeah and this is what you're looking at is survival I mean it is unbelievably effective uh survival because at the time we used gemcitabin it was it was only used for patients who weren't fit enough for the new more toxic regimens that come in so that the survival was even more important because the the standard patient we treated was so poorly and yet we had this fantastic Improvement if you gave the
IMM and Gem the survival was far superior to gem site have been alone I just like to add though one other thing that never ever um Tire of saying is that when I was asked why this IM theapy worked so well by a guy in in America when we presented it he said why does none of the other IM therapies work in pancreatic cancer and I said well this is probably the first trial where we insisted that the vitamin D levels had to get into the normal range he subsequently he couldn't believe this he said
I've never heard of this and I'm a very big pancreatic Tri cancer person his name was Daniel vonhof and he was quite uh he was huffing and puffing about this he didn't like but he phoned Me 3 months later to say he' put somebody on a study to check he'd done 4,000 patients on different trials over over two to three decades and he came back and he said not a single Patient responded to a single chemotherapy agent if they had a low vitamin D level he was absolutely knocked out and the really good ones that
they put down down to the later agents as they came along in the trials that the responses were purely correlated with the fact these rare patients at high vitamin D level so this and so the with this it's one of the things I've always said we're going to stimulate the anate immune system you must have a good vitamin D level first which makes perfect sense because you've got vitamin D receptors in every type of white blood cell you've got vitamin D genomic expression that depends on uh vitamin D dependent genomic expression in every type of
white blood cell it seems it seems fairly obvious interestingly though that the patients with the high levels of vitamin D in the blood did they actually do better was there like a dose response there yes yes there was he confirmed that he said he couldn't believe it I mean he spent 30 years doing this and hadn't uh uh realized it was that simple well I I must confess that we took a while before we realized that the difference between a responder and a non-responder was the vitamin D we looked at virtually everything else and we
only cottoned on to vitamin D when we were able to use the hospitals vitamin D testing service that they use for mothers and babies relative to rickets and as soon as we could do it for adults we found that it was it was the same the only people who responded really well to the the vaccines including the immune modulators like IMM were the people who had good healthy vitamin levels it also highlighted that the nhs's idea of a normal vitamin D is really too low at least in this pathological situation in the pathological situation because
vitamin D is too low in the general population because this is a population that SP is uh very wh skinned uh and uh exists in IND doors most of the time so it doesn't get a chance and then people who have got darker skins it is far far worse so they need definitely need supplementation it's interesting so for years you'd known that some patients respond to your chemotherapeutic regimes and some don't and the reason that the nonresponders didn't respond is because they were low on vitamin D it was that simple yeah it is that simple
they so obvious once you know but so what sort of levels do you like to titrate up to for chemother over I like to get it over 100 Nomes per liter yeah uh the NHS normal is 50 nanom per liter so that's it's far too low yeah so over 100 but that's still only about sort of 35 40 NRS per mil isn't it it's not yeah and you know the upper limit of normal is usually 200 to 220 so it's nowhere near toxic no absolutely nobody near and even then in your career have you seen
a case of vitamin D induced hypercalcemia I it's it's very difficult to say in my direct question is no but I have heard of it occurring in children where the mothers are given ludicrous high doses because the kidneys can't take it you you've got to be very careful giving vitamin D supplementation in renal failure right and certain people with rare phosphate genetic pathway abnormalities apart from that you you normally just pee it out if any excess you have a uh thermostat and once the vitamin D goes I mean there's some people you can give grams
too nearly and they'll never go above 120 interesting even though it's a fat soluble vitamin CU traditionally I would teach that it's water soluble vitamins that are urine excreted but here we have a fat soluble vitamin that's actually urine excreted you can test the urine and find high levels of vitamin D in the urine if if you give if you give large amounts it's just um yeah it just seems complete no-brainer not to do that um it is this done now in cancer centers around the country is vitamin D replete slowly but I just cannot
believe the number of people I get referred for second opinion you know will you please see this person they've been on all the right treatment they're not responding have you got any sort of magic this that and the other and I find they've never had their vitamin D measured from you know big Cancer Centers which I won't name but and I measure the vitamin D and it's really low so I that's the first thing I do Boost it up and I thought that should not be my job no it should the the should shouldn't get
your professor to do that the junior should do that well exactly anyone comes near me should have a very good vitamin D level it's not my job to point out you've just had a year of treatment it's a total waste of time because you got a low vitamin D level it's unbelievable and the human suffering and the financial cost involved in that it's just unbelievable but even hospitals with uh very good reputations are are not getting vitamin D measured in a lot of their patients y incredible in fact the people who do push for it
are actually the dietitians yes not the doctors not the oncologists the oncologists will say well there no good evidence of course this good evidence they just never never ever bother to do the research on it so two Natural Things the imn which is is is is the micob bacterium attenuated bacterial preparation the vitamin D Perfectly Natural and and getting those two things right has got this massive benefit
