plume it for men plume it for trt plume it for low testosterone plummet for man's fertility those are all youtube search terms that are very popular so can you cover them all in one short video [Music] [Applause] [Music] okay Gil welcome back to our Channel thank you Steve and I will be here as always plume it for man plume it for TRT plume it for low testosterone plummet for man's fertility those are all YouTube's search terms that are very popular so can you cover them all in one short video absolutely clomid is the nickname for
medication called clomiphene citrate it's an oral medication it is often dosed in 50 milligrams sometimes 25 and then if it's broken into four twelve and a half it's designed as a fertility drug and it's indicated for fertility specifically and it's a class of medications known as a CIRM scorm which stands for selective estrogen receptor modulators what this class of medications essentially does is it does not directly act on a hormone by changing directly it doesn't directly and I'll get to that in a minute it doesn't directly change hormone levels in the body it simply blocks
the receptor sites or the active sites of the cell else that are going to receive that hormone signal and then effectively have a chemical reaction to it so by occupying a receptor site without actually activating it what you're essentially doing is you're mimicking a low state of serum for that hormone because our endocrine system as we know has two types of mechanisms positive feedback which is less common and negative feedback example of a positive feedback would be something like oxytocin which works on contraction of memory gland tissue for breastfeeding as well as uterus contractions so
this is something that is is common for women when they when they give birth but the negative feedback system is the one that we're more familiar with for the general tropic hormones that stimulate production and glands within the endocrine system and that would be our sex hormones various different steroids or metabolic function through the thyroid and so forth adrenal cortex and whatnot so they're not going to feedback is very when one signal goes up the production of the other hormone will go up and when that hormone is sufficient the signaling hormones will come down so
it's kind of like a Cecil effect our pituitary gland which is the master gland of the endocrine system is very heavily regulated by negative feedback mechanisms specifically the interior pituitary or adeno hypothesis as it's also known and this gland is very sensitive to how the receptors in that land are being a ganar either by various compounds so estrogen as it elevates in our blood from the process of romanization enters the blood serum circulation hits the pituitary gland as well as the hypothalamus but I won't get into that one let's let's focus on the pituitary it
essentially tells our signal in our brain we have enough you can go ahead and turn that faucet off now and that's when your luteinizing hormone essentially would be diminished and follicle stimulating hormone follows along as well when you're taking clomiphene or a class of a SERM type medication what you're doing is you're occupying the estrogen receptor systemically but some of them have a bigger binding affinity to some parts of the body than others and climate is exceptionally strong in the brain so it does the block a lot of the estrogen signaling in the brain and
it tells your body you're in a constant state of Andry or estrogen deficiency essentially or a low state of estrogen as a result your testicles will kick on your pituitary will pump up more LH and the LH will stimulate more testosterone production this is commonly why we see men who suffer from secondary hypogonadism which is not specific difficult a stickler hypofunction induced by late Excel desensitization but more so testicular hypofunction secondary to the pituitary failing to put out kanata to open signals this will spike in editor open signals so on the labs you're gonna see
that all of a sudden that testosterone levels are shooting way up and the guide doesn't report to feel any better initially they may but then very quickly that subsides and then as time goes by over the course of three or six months assuming they're using a clomid mono therapy approach you're gonna notice that the mood swings start to come in depression sets in libido begins to diminish and all the metabolic benefits of estradiol begin to diminish weight gain begins to set in etc and this is directly a result of while estrogen serum and presumably paracrine
levels are sufficient they're not able to act on the target tissues so some almost like saying you got all this money in the bank but you can't use it you're still poor right you're gonna suffer the poverty symptoms if I put a million dollars in your bank account and I don't give you access to it for ten years you're still living in poverty and this is essentially what a sermon does so it has its place in a short-term kickstart or a short-term fertility spurt it does not have a valid place in a replacement therapy for
trt because it is often short-lived it causes more damage than it does good and as soon as you take guys off over ninety percent of the patients who have done fairly well on paper are going to crash back then so it is an unsustainable approach and I dislike it I do understand why the medical community uses it and it's primarily more for litigation mitigation okay specifically in younger patients they want to say well we've tried all of the non-invasive methods first they failed and now we're going to go ahead and put the guy on tier
T but at least they can chart and document that they've made every viable attempt and they know damn well it's gonna fail but again they do this more to cover their butts and be able to say that we didn't just resort to T or T out of the gate and I dislike that part of medicine again this comes down to doing things that you know we're incorrect for the sake of satisfying the legal system and that's that's up for discussion but in short clomid has a negative side effects including depression potential sexual dysfunctions and including
some vision loss because remember you're also blocking some of the estrogen receptors related to the optic part of the eye which in the back of the eye you have some some estradiol that's responsible for some of your vision and when you block that you're also going to experience potential floaters and over time I mean the longer you stay on it's also dose dependent you may develop hyperopia so not something that is recommended for patients especially long-term in lieu of tea or tea whether the use of this product come from any medical worth it from the
body building because it was used as PCT yeah so it's very common in the bodybuilding world to do what's known as a cycle and a cycle is essentially a short-lived run of anabolic steroids ranging from ten twelve sixteen I've seen 20 24 weeks etcetera but however long a cycle is it usually uses some compounds that are suppressive or inhibit or shut down the natural production of the hypothalamic pituitary testicular axis so in order to kick-start that production and avoid for a younger bodybuilder to stay on a low-dose testosterone indefinitely what they do is they do
what's known as a pulse psychotherapy or a kickstart of their H BTA and the way they do this is they use a Gannett Ropin mimic art like human chorionic gonadotropin for a period of time this kick starts the testicular function and then that's followed up with a sirum other tamoxifen a cane all the decks or clomid or any class of firms that essentially is going to help kick-start the pituitary glands so again it has its place in a kickstart protocol it does not have its place as a replacement therapy if you will for the the
reasons I mentioned earlier so I think that the bodybuilding community certainly put that into the mix long ago I think going back to the to the 70s is when it was used most commonly and it just kind of lingered and it's still being used today in bodybuilding however a lot more guys are kind of staying on T all year round now moderate doses because they realize that turning the switch on and off continuously will eventually fry your pituitary function and you're not going to recover so why the medical community chooses to use this again I
can understand if it's a very young person if there is a legitimate at lifestyle perhaps reason for why their pituitary function is diminished we can certainly try a short-term kickstart again I'm not I'm not a big fan of kilometer for the side effects however even if the side effect profile is short-lived a lot of people are really over doing and they're doing it in the wrong patient where there's just no chance of recovery ok very clear time skill [Music]
