A VERDADE QUE VOCÊ PRECISA SABER SOBRE A DIPIRONA!

Hey guys! All good? Are we going to talk about dipyrone today?

Almost everyone has a bottle of dipyrone at home, or some pill to use when they feel pain, right? Did you know that he is one of the most used remedies in the world? It is a non-opioid analgesic medicine, used in cases of pain, inflammation, also very effective in lowering fever, an important detail: dipyrone can be used even by cardiac patients who are hospitalized in the ICU, for example.

It can be used by those with hypertension, by those who have already had a heart attack or are at risk of having a heart attack, it can be used in patients with heart failure , that is, dipyrone can replace anti-inflammatory drugs in many cases, especially if you are a heart patient. Remember that I've already said a few times that if you have any cardiovascular disease, you have to avoid the use of anti-inflammatories as much as possible, such as diclofenac, ibuprofen, nimesulide, among many others. So stay with me until the end of this video, you'll know everything about dipyrone, what it's for, how it works in your body, and about the side effects that you can't even imagine.

So, without further ado, run the vignette! Doctor Roberto Yano, Cardiologist. Hello heart friends!

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I always say that patients with some type of cardiovascular disease should not use anti-inflammatory drugs. Because the anti-inflammatory can increase the risk of other cardiovascular diseases, such as a stroke, a heart attack, and so on. But what can a person with cardiovascular disease use when they have pain?

Or when you have some kind of inflammation? An alternative to anti-inflammatory drugs is the use of dipyrone, which is also one of the best selling drugs in the world. Dipyrone has analgesic, antipyretic and anti-inflammatory properties.

That is, it can be used for various types of pain: headache, joint pain, muscle pain. In addition, it also lowers fever and also acts as an anti-inflammatory. It has the ability to inhibit the production of prostaglandins, which are substances involved in inflammation and pain.

So, it acts by inhibiting COX, which is the cyclooxygenase enzyme, responsible for the production of prostaglandins. These prostaglandins are chemical mediators that have several functions in our body. They regulate body temperature, vasodilate and sensitize pain receptors, when we are injured or when there is some inflammation in our body, cyclooxygenase is activated and begins to produce prostaglandins.

This ends up increasing our pain, increasing inflammation, sometimes even causing a fever. Dipyrone then acts by inhibiting COX, reducing prostaglandins, then you have a reduction in pain, inflammation, fever, although it has an anti-inflammatory action, this action is not as potent as that of non-steroidal anti-inflammatory drugs, that you know around, diclofenac, nimesulide, ibuprofen. Although its anti-inflammatory action is not as potent, it is preferable mainly in people with some cardiovascular disease, for pain relief.

As I said before, we Cardiologists prescribe dipyrone for pain even in patients admitted to the ICU, after cardiac catheterization, after a heart attack, or even in patients who have just had heart surgery, so it is a very safe medication. We know that using anti-inflammatory drugs can increase the risk of cardiovascular events in patients with a history of cardiovascular disease. So, it increases the chances of having a heart attack, stroke, heart failure, in addition to anti-inflammatories inhibiting COX, inhibiting prostaglandins, the inhibition of cyclooxygenase can also affect the production of other substances such as prostacyclins, which have vasodilator properties, anti-platelet aggregation, that is, help to prevent the formation of clots blood.

So in patients with cardiovascular disease, anti-inflammatories can reduce the production of prostacyclins, increase the production of thromboxanes, which are pro-thrombotic substances. And what does that entail? Increased cardiovascular risk.

Heart attack, stroke and heart failure. That's why in patients with a history of heart attack or other heart diseases, the patient has to avoid the use of anti-inflammatory drugs. Instead, we recommend the use of analgesics such as dipyrone, in appropriate doses, of course, for short periods and always under medical supervision.

It's important for you to understand that it's not just going to the pharmacy and buying dipyrone, you have to get guidance from your doctor because this recommendation depends on your case, your history of illnesses. Dipyrone is indeed a safe analgesic, but like any medicine it can cause side effects and have interactions with other medications. Do you know, for example, someone who is allergic to dipyrone?

Then comment here if you know someone. Guys, did you know that Clínica Yano is now here in Indaiatuba? So you from Indaiatuba, Campinas, São Paulo, I didn't say Americana the other time and they got mad, from Americana, Limeira, Sorocaba, Itu, Salto, anyway, you can consult with us now in person, here in Indaiatuba.

We are in Indaiatuba. Also, don't forget to follow me on Instagram, guys. My Instagram is @dr.

yano. There are many fake profiles out there, but mine is the one with the verification badge, it's @dr. yano.

If you notice fake profiles, report them. And what are the side effects of this commonly used pain reliever? First, it can give an allergic reaction.

Dipyrone can indeed cause severe allergic reactions, even anaphylactic shock, which is a medical emergency. Other symptoms that may occur are hives, itching, body redness, swelling. Sometimes difficulty breathing, low blood pressure, so if you experience any of these symptoms, seek immediate medical attention.

At the hospital, or even at the doctor's office, we usually ask the patient if he is allergic to any medication. I've seen people say they are allergic to dipyrone because they had nausea, for example. Just having nausea doesn't mean you had an allergic reaction to the medication.

It could have just been a side effect of the medicine. Dipyrone can also cause problems in the gastrointestinal tract, it can cause nausea, vomiting, cause irritation in the stomach, intestine, abdominal pain, sometimes diarrhea and in rare cases even ulcers. Some people may have an effect on the nervous system, have dizziness, vertigo, drowsiness, even mental confusion, but this is rarity of rarity.

When it is used in high doses without medical advice, that abusive use can cause liver and kidney problems. So never take medicine, any medicine, without your doctor's guidance. In addition, dipyrone can also cause problems in the blood system.

Rarely, dipyrone can cause anemia, a decrease in the number of white blood cells, in addition to these side effects, dipyrone can also interact with other medications, including anticoagulant, antihypertensive, diabetes medication, and other analgesics. That's why I always say, inform your doctor about all the medications you are taking before starting, or before taking dipyrone. If you are seen in an emergency room by a doctor who does not know your history, always remember to pass along the entire list of medications you use to avoid these drug interactions, he can prescribe dipyrone for you without any problem.

And just out of curiosity, did you know that dipyrone is not sold in the US? Dipyrone is used in Europe, Latin America, Asia, but in the US they they use another analgesic, which is paracetamol, which is also available in Brazil. Paracetamol can also be used in cardiac patients, always with medical guidance.

This medication does not have an anti-inflammatory effect as strong as dipyrone, it is more to relieve pain, it also lowers the fever. It is important to know that paracetamol can also interact with other medications, so it depends on the health condition of each patient. For example, paracetamol should be used with caution in patients with liver disease, or in combination with other drugs that affect the liver.

Because excess paracetamol can lead to liver damage. In addition, there is a maximum dose per day. Beyond that dose, it can become toxic and in some cases even fatal.

Alright guys, so if you liked the video, share it in your WhatsApp groups, if you have a hypertensive friend and you're always stuffing yourself with anti-inflammatories, send him this video, sometimes you send this video it can be helping even save his life. All right, guys! Today's message is this!

A big hug and until next time.